Life

You May Have A Gene That Makes You Fat, Rendering Your Diet Useless, So Eat That Extra Pizza Slice

“There is this common belief in the field that much of obesity can be traced back to appetite and the appetite control centers that reside in the brain,” says Bennett. “But what if it isn’t all in our head?” There are estimates that 8.4% of African Americans and 1.3% of European Americans possess some kind of mutation in the ankyrin-B gene which could cause them to be more obese than others. Researchers believe high-fat diets could be devastating for those with the gene mutation, even when they’re eating fewer calories. “This gene could enable us to identify at-risk individuals who should watch what kind of calories they eat and exercise more in order to keep their body weight under control,” says Bennett.

Based on a number of biochemistry experiments, Damaris Lorenzo, Ph.D. found that mice with ankyrin-B gene mutations quickly grew fat, locking away most of their calories in fat tissue rather than sending them to other tissues to burn as energy. By altering or removing ankyrin-B completely, it changed a protein called Glut4, which controls the rate that glucose enters fat cells. When ankyrin-B is altered, glucose flows easily and quickly into fat cells at a higher rate than normal, resulting in these cells expanding. Generally, there is a plasma membrane that prevents glucose from entering these cells; the alteration allowed the glucose to flood in.

So there are actually some people who may legitimately look at food and get fat. So it’s not your fault that you’re husky (If you have this mutation). This is the best fatty news since science said to eat a second burger instead of fries. However, let’s keep in mind that this is still an early study and it only affects SOME people. So that means don’t eat Uno’s Pizza Skins and half of a deep dish Chicago Classic pie then cry and blame your 20-pound weight gain on your genes.

[NewAtlas]

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